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Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles
Article in English | WPRIM | ID: wpr-775007
Responsible library: WPRO
ABSTRACT
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly water-soluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up.

ACN, acetonitrile; CA 320S Seb, cellulose acetate 320S sebacate; CAP Adp 0.33, cellulose acetate propionate 504-0.2 adipate 0.33; CAP Adp 0.85, cellulose acetate propionate adipate 0.85; CFA, cefuroxime axetil; CIJM, confined impinging jets mixer; CMCAB, carboxymethyl cellulose acetate butyrate; CTACl, cetyltrimethylammonium chloride; DMF, dimethyl formamide; DMSO, dimethyl sulfoxide; DSPE-PEG, distearyl phosphatidyl ethanolamine-poly(ethylene glycol); Dex-PLLA, dextrose-poly(l-lactic acid); FNP, flash nanoprecipitation; Flash nanoprecipitation; HPC, hydroxypropyl cellulose; HPMC, hydroxypropyl methyl cellulose; HPMCAS, hydroxypropyl methylcellulose acetate succinate; MIVM, multi-inlet vortex mixer; Microfluidic mixer device; NaAlg, sodium alginate; NaCMC, carboxymethyl cellulose sodium; Nanoparticles; P(MePEGCA-co-HDCA), poly(methoxy polyethylene glycol cyanoacrylate-co-hexadecyl cyanoacrylate); PAA, poly(acrylic acid); PAH, polyallylamine hydrochloride; PCL, poly(ε-caprolactone); PEG, polyethylene glycol; PEG-PCL, poly(ethylene glycol)-poly(ε-caprolactone); PEG-PLA, poly(ethylene glycol)-poly(lactic acid); PEG-PLGA, poly(ethylene glycol)-poly(lactic-co-glycolic acid); PEG-PS, poly(ethylene glycol)-polystyrene; PEI, polyethyleneimine; PEO-PDLLA, poly(ethylene oxide)-poly(d,l-lactic acid); PLA, poly(lactic acid); PLGA, poly(lactic-co-glycolic acid); PMMA, polymethyl methacrylate; PSS, polyprotomine sulfate; PVA, polyvinyl alcohol; PVP, polyvinyl pyrrolidone; Poorly water-soluble drug; SDS, sodium dodecyl sulfonate; SLS, sodium lauryl sulfate; THF, tetrahydrofuran; TPGS, tocopheryl polyethylene glycol 1000 succinate; ε-PL, ε-polylysine
Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2019 Type: Article