Your browser doesn't support javascript.
loading
Effect of augmented renal clearance on plasma concentration of vancomycin and treatment outcome in children with methicillin-resistant Staphylococcus aureus infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 904-909, 2019.
Article in Chinese | WPRIM | ID: wpr-775084
ABSTRACT
OBJECTIVE@#To investigate the effect of augmented renal clearance (ARC) on plasma concentration of vancomycin, bacteriological outcome, and clinical outcome in children with methicillin-resistant Staphylococcus aureus (MRSA) infection treated by vancomycin.@*METHODS@#A retrospective analysis was performed for the clinical data of 60 critically ill children who were treated with vancomycin due to MRSA infection from January 2013 to July 2017 and underwent plasma concentration monitoring. According to estimated glomerular filtration rate, these children were divided into an ARC group with 19 children and a normal renal function group with 41 children. The two groups were compared in terms of the use of vancomycin, plasma concentration of vancomycin, and treatment outcome.@*RESULTS@#The children in the ARC group had an age of 1-12 years, and the ARC group had significantly higher body weight and body surface area than the normal renal function group (P0.05), but the ARC group had significantly longer length of stay in the pediatric intensive care unit (PICU) and length of hospital stay than the normal renal function group (P<0.05).@*CONCLUSIONS@#ARC can significantly reduce the trough concentration of vancomycin and prolong the length of PICU stay and the length of hospital stay in children with MRSA infection. Idividualized medication should be administered to children with ARC.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Staphylococcal Infections / Vancomycin / Retrospective Studies / Treatment Outcome / Therapeutic Uses / Drug Therapy / Methicillin-Resistant Staphylococcus aureus / Methicillin / Anti-Bacterial Agents Type of study: Observational study Limits: Child / Child, preschool / Humans / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Staphylococcal Infections / Vancomycin / Retrospective Studies / Treatment Outcome / Therapeutic Uses / Drug Therapy / Methicillin-Resistant Staphylococcus aureus / Methicillin / Anti-Bacterial Agents Type of study: Observational study Limits: Child / Child, preschool / Humans / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article