Risk factors of death in newborns with congenital diaphragmatic hernia / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 83-88, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775250
ABSTRACT
To investigate risk factors of death in newborns with congenital diaphragmatic hernia (CDH). A total of 126 newborns with CDH from June 2012 to September 2018 were enrolled. Concomitant malformations were recorded by descriptive analysis. Newborns received surgical treatment (=120) for CDH were divided into survival group and fatal group. The risk factors of death were analyzed by univariate and multivariate logistic regression and the ROC curve with generated with relevant variables. There were 55 CDH newborns with concomitant malformations (43.7%), including 20 cases (15.9%) with multi-malformation. Logistic regression analysis showed that premature rupture of membranes (PROM), postoperative atelectasis, long duration of postoperative mechanical ventilation, postoperative high oxygenation index (OI) were related to death (all <0.05), and the delayed surgery was a protective factor (<0.05). In ROC analysis of postoperative OI in predicting death, the area under the curve (AUC) was 0.841, with the cutoff value of 5.74, the sensibility and specificity of OI was 81.0% and 75.0%, respectively(<0.01). Newborns with CDH have a high rate of malformations. The risk factors of death were PROM, postoperative atelectasis, postoperative long duration of mechanical ventilation and higher postoperative OI, and delayed surgery may reduce mortality.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Logistic Models
/
Retrospective Studies
/
Risk Factors
/
ROC Curve
/
Mortality
/
Sensitivity and Specificity
/
Diagnosis
/
Hernias, Diaphragmatic, Congenital
/
Infant Death
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2019
Type:
Article
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