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Graft failure in allogeneic hematopoietic stem cell trans-plantation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 651-658, 2018.
Article in Chinese | WPRIM | ID: wpr-775265
ABSTRACT
With the progress of medical technology, the development of new drugs and the improvement of the therapeutic effect of graft-versus host disease in the last two decades, the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) have been greatly improved. However, graft failure is still a rare but serious complication of allo-HSCT. HLA incompatibility, virus infection, elderly donor, uncontrolled primary disease, damage of bone marrow hematopoietic microenvironment, ABO blood group incompatibility, T cell depletion, reduced intensity conditioning, and low nucleated cell number are all risk factors for graft failure. In recent years, with the implementation of HLA haplo-identical hematopoietic stem cell transplantation, the role of donor-specific antibodies in graft failure has attracted attention increasingly. This article reviews the recent studies involving the mechanism, risk factors and prevention measures of graft failure in allo-HSCT.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Standards / Transplantation, Homologous / Epidemiology / Risk Factors / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease Type of study: Etiology study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Reference Standards / Transplantation, Homologous / Epidemiology / Risk Factors / Hematopoietic Stem Cell Transplantation / Transplantation Conditioning / Graft vs Host Disease Type of study: Etiology study / Risk factors Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2018 Type: Article