Graft failure in allogeneic hematopoietic stem cell trans-plantation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 651-658, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-775265
ABSTRACT
With the progress of medical technology, the development of new drugs and the improvement of the therapeutic effect of graft-versus host disease in the last two decades, the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) have been greatly improved. However, graft failure is still a rare but serious complication of allo-HSCT. HLA incompatibility, virus infection, elderly donor, uncontrolled primary disease, damage of bone marrow hematopoietic microenvironment, ABO blood group incompatibility, T cell depletion, reduced intensity conditioning, and low nucleated cell number are all risk factors for graft failure. In recent years, with the implementation of HLA haplo-identical hematopoietic stem cell transplantation, the role of donor-specific antibodies in graft failure has attracted attention increasingly. This article reviews the recent studies involving the mechanism, risk factors and prevention measures of graft failure in allo-HSCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Standards
/
Transplantation, Homologous
/
Epidemiology
/
Risk Factors
/
Hematopoietic Stem Cell Transplantation
/
Transplantation Conditioning
/
Graft vs Host Disease
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2018
Type:
Article
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