Progress on cancer associated fibroblasts in tumor immunoregulation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 558-563, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-775279
ABSTRACT
Cancer associated fibroblasts (CAFs) are important components of the tumor microenvironment. Through secreting of multiple growth factors, cytokines and proteases, CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment. In addition, extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment. Here, we review the progress on CAFs in regulation of immune cells and tumor immunity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Allergy and Immunology
/
Extracellular Matrix
/
Tumor Microenvironment
/
Cancer-Associated Fibroblasts
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2018
Type:
Article
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