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Study on fragmentation pathways of three ginkgolides by mass spectrometry / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 4093-4096, 2018.
Article in Chinese | WPRIM | ID: wpr-775373
ABSTRACT
The fragmentation pathways of the three ginkgolides (ginkgolides A, ginkgolides B, ginkgolides C) have been studied with high resolution and high mass accuracy using quadrupole time-of-flight mass spectrometry in negative ion mode in this paper. The results indicate that the three ginkgolides have similar fragmentation pathways, including four kinds of common cleavage pathways and one common characteristic ion. In high quality regions, the typical fragmentation pathways of the three ginkgolides are lactone ring opening with continuous loss of CO, CO₂,and loss of H₂O. In low quality regions, the common characteristic fragment ion of the three ginkgolides at 72.993 6 is formed by C rings cleavage. Also, the common fragment ions of ginkgolides A and ginkgolides B at 141.018 8, 125.023 8, 113.024 0, 97.029 1 are formed by A rings cleavage. The study of fragmentation pathways could be adopted for the structural identification of the ginkgolides and their metabolites.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Mass Spectrometry / Chemistry / Spectrometry, Mass, Electrospray Ionization / Ginkgolides Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Mass Spectrometry / Chemistry / Spectrometry, Mass, Electrospray Ionization / Ginkgolides Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2018 Type: Article