A new isobenzofuranone derivative from Phlomis betonicoides and its antibacterial activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4074-4076, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-775376
ABSTRACT
A new isobenzofuranone derivative has been isolated from Phlomis betonicoides by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compound was determined as 5-(3-hydroxypropyl)-2,2-dimethyl-2-furo[3,4-]chromen-7(9)-one (1) by NMR, MS, IR and UV spectroscopic data. Compound 1 showed potent antibacterial activity with an MIC₉₀ value of (58.4 ± 4.2) mg·L⁻¹ for methicillin resistant Staphylococcus aureus (MRSA) strain [levofloxacin as a control with MIC₉₀ value of (52.8±4.6) mg·L⁻¹].
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Benzofurans
/
Microbial Sensitivity Tests
/
Chemistry
/
Phlomis
/
Methicillin-Resistant Staphylococcus aureus
/
Phytochemicals
/
Anti-Bacterial Agents
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Type:
Article
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