Research progress on anti-inflammatory mechanism of natural sesquiterpenoids / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3989-3999, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-775387
ABSTRACT
Sesquiterpenoid is a kind of compound widely distributed in nature, which has a wide range of biological activities, such as anti-inflammatory, anti-tumor and immunomodulatory activities. This paper would review the anti-inflammatory mechanism of sesquiterpenoid. The mechanism is mainly by inhibiting the activation of nuclear factor (NF-κB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor- (TNF-), prostaglandin E₂ (PGE₂), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Thereby, the production and release of inflammatory cytokines are reduced to exert anti-inflammatory effect. This review is intended to provide reference for related research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sesquiterpenes
/
Dinoprostone
/
Signal Transduction
/
NF-kappa B
/
Interleukins
/
Tumor Necrosis Factor-alpha
/
MAP Kinase Signaling System
/
STAT Transcription Factors
/
Anti-Inflammatory Agents
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Type:
Article
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