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Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 461-470, 2019.
Article in English | WPRIM | ID: wpr-775428
Responsible library: WPRO
ABSTRACT
Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage (SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin (100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAH-induced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca overload. Moreover, gastrodin suppressed the SAH-induced microglial activation, astrocyte activation, and neuronal apoptosis. Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1, phospho-Akt and B-cell lymphoma 2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. Our results suggested that the administration of gastrodin provides neuroprotection against early brain injury after experimental SAH.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Subarachnoid Hemorrhage / Benzyl Alcohols / Brain / Brain Edema / Male / Blood-Brain Barrier / Astrocytes / Calcium / Rats, Sprague-Dawley / Apoptosis Language: English Journal: Neuroscience Bulletin Year: 2019 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Subarachnoid Hemorrhage / Benzyl Alcohols / Brain / Brain Edema / Male / Blood-Brain Barrier / Astrocytes / Calcium / Rats, Sprague-Dawley / Apoptosis Language: English Journal: Neuroscience Bulletin Year: 2019 Type: Article