Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1058-1066, 2018.
Article
in English
| WPRIM
| ID: wpr-775472
ABSTRACT
While inflammatory bowel disease (IBD) might be a risk factor in the development of brain dysfunctions, the underlying mechanisms are largely unknown. Here, mice were treated with 5% dextran sodium sulfate (DSS) in drinking water and sacrificed on day 7. The serum level of IL-6 increased, accompanied by elevation of the IL-6 and TNF-α levels in cortical tissue. However, the endotoxin concentration in plasma and brain of mice with DSS-induced colitis showed a rising trend, but with no significant difference. We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis. These results suggested that DSS-induced colitis increases systemic inflammation which then results in cortical inflammation via up-regulation of serum cytokines. Here, we provide new information on the impact of colitis on the outcomes of cortical inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Polysaccharides
/
Time Factors
/
Blood
/
Calcium-Binding Proteins
/
Cerebral Cortex
/
Gene Expression Regulation
/
Cytokines
/
Dextran Sulfate
/
Colitis
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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