Your browser doesn't support javascript.
loading
Laminar Distribution of Neurochemically-Identified Interneurons and Cellular Co-expression of Molecular Markers in Epileptic Human Cortex / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 992-1006, 2018.
Article in English | WPRIM | ID: wpr-775482
ABSTRACT
Inhibitory GABAergic interneurons are fundamental elements of cortical circuits and play critical roles in shaping network activity. Dysfunction of interneurons can lead to various brain disorders, including epilepsy, schizophrenia, and anxiety. Based on the electrophysiological properties, cell morphology, and molecular identity, interneurons could be classified into various subgroups. In this study, we investigated the density and laminar distribution of different interneuron types and the co-expression of molecular markers in epileptic human cortex. We found that parvalbumin (PV) and somatostatin (SST) neurons were distributed in all cortical layers except layer I, while tyrosine hydroxylase (TH) and neuropeptide Y (NPY) were abundant in the deep layers and white matter. Cholecystokinin (CCK) neurons showed a high density in layers IV and VI. Neurons with these markers constituted ~7.2% (PV), 2.6% (SST), 0.5% (TH), 0.5% (NPY), and 4.4% (CCK) of the gray-matter neuron population. Double- and triple-labeling revealed that NPY neurons were also SST-immunoreactive (97.7%), and TH neurons were more likely to express SST (34.2%) than PV (14.6%). A subpopulation of CCK neurons (28.0%) also expressed PV, but none contained SST. Together, these results revealed the density and distribution patterns of different interneuron populations and the overlap between molecular markers in epileptic human cortex.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Parvalbumins / Pathology / Phosphopyruvate Hydratase / Physiology / Tyrosine 3-Monooxygenase / Neuropeptide Y / Brain Chemistry / Cholecystokinin / Somatostatin / Cerebral Cortex Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Neuroscience Bulletin Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Parvalbumins / Pathology / Phosphopyruvate Hydratase / Physiology / Tyrosine 3-Monooxygenase / Neuropeptide Y / Brain Chemistry / Cholecystokinin / Somatostatin / Cerebral Cortex Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Neuroscience Bulletin Year: 2018 Type: Article