Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 98-112, 2019.
Article
in English
| WPRIM
| ID: wpr-775484
ABSTRACT
Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes. Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances (such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Pressoreceptors
/
Blood Pressure
/
Cardiovascular Diseases
/
Baroreflex
/
Diabetes Mellitus
/
Ion Channels
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2019
Type:
Article
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