Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 715-724, 2018.
Article
in English
| WPRIM
| ID: wpr-775494
ABSTRACT
Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion (MCAO) at the acute stage using F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO. Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together, the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Brain Mapping
/
Diagnostic Imaging
/
Random Allocation
/
Acute Disease
/
Rats, Sprague-Dawley
/
Radiopharmaceuticals
/
Fluorodeoxyglucose F18
/
Infarction, Middle Cerebral Artery
/
Positron-Emission Tomography
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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