Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 849-853, 2018.
Article
in English
| WPRIM
| ID: wpr-775507
ABSTRACT
As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson's disease (PD). Here, we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which has been widely used for creating a mouse model of PD. Exposure to 2 h of restraint stress immediately after injection of a low dose of MPTP caused a severe loss of striatal dopaminergic terminals as indicated by decreases in the dopamine transporter protein and dopamine levels compared with MPTP administration alone. Both striatal 1-methyl-4-phenylpyridinium ion (MPP) and MPTP concentrations were significantly increased by the application of restraint stress. Striatal monoamine oxidase-B, which catalyzes the oxidation of MPTP to MPP, was not changed by the restraint stress. Our results indicate that the enhanced striatal dopaminergic terminal loss in the stressed mice is associated with an increase in the transport of neurotoxin into the brain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stress, Psychological
/
Restraint, Physical
/
1-Methyl-4-phenylpyridinium
/
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/
Corpus Striatum
/
MPTP Poisoning
/
Disease Models, Animal
/
Dopaminergic Neurons
/
Metabolism
/
Mice, Inbred C57BL
Type of study:
Prognostic study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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