Expression and Clinical Significance of Cancer-derived Immunoglobulin G in Non-small Cell Lung Cancer by Bioinformatics and Immunohistochemistry / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 341-348, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775622
ABSTRACT
BACKGROUND@#It was believed that immunoglobulin G (IgG) was synthesized only by B cells. However, in recent years, researchers have found that a variety of cancer cells can also synthesize IgG (cancer-IgG) which promote the development of tumors. This study analyzed the expression and clinical significance of cancer-IgG in non-small cell lung cancer (NSCLC), and initially explored its mechanism.@*METHODS@#The expression of IgG1 heavy chain gamma 1 (IGHG1) and cancer-IgG were detected by bioinformatics and immunohistochemistry in NSCLC; The gene set enrichment analysis (GSEA) method was used to explore the signaling pathways involved in IGHG1 regulation.@*RESULTS@#The expression level of cancer-IgG in NSCLC was significantly higher than that in normal tissues. The high expression group had a poor prognosis and was associated with clinical stage (P=0.042), T stage (P=0.044) and metastasis (P=0.007). GSEA analysis showed that IGHG1 was associated with cell adhesion, cytokine interaction and chemokine signaling pathway.@*CONCLUSIONS@#High expression of cancer-IgG in NSCLC is a poor prognosis factor, which may be related to the promotion of tumor invasion and metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunoglobulin G
/
Immunohistochemistry
/
Carrier Proteins
/
Biomarkers, Tumor
/
Carcinoma, Non-Small-Cell Lung
/
Computational Biology
/
Genetics
/
Lung Neoplasms
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2019
Type:
Article
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