Identification of A Case of DEL Blood Group with DAT Positive Phenotype and Pedigree Analysis / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1649-1653, 2019.
Article
in Zh
| WPRIM
| ID: wpr-775670
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To identify the blood group of a patient with DEL phenotype combined with positive direct anti-human globulin test and to analyze the pedigree.@*METHODS@#Routine serological reagents were used for serological analysis of RhD blood group in the pedigree members. Exons and flanking sequences of RHD gene were amplified, sequenced and analyzed for heterozygosity. The familial genetic state of DEL phenotype was further analyze in the family members.@*RESULTS@#The DAT was strongly positive in the proband. The 1227G>A allele (RHD*DEL1) was present in the exon 9 of RHD gene, and the mother was the carrier of RHD*DEL1. The proband was identified as RHD+/RHD-, suggesting the CDe/Cde haplotype.@*CONCLUSION@#The proband is DEL phenotype (RHD*DEL1).
Full text:
1
Index:
WPRIM
Main subject:
Pedigree
/
Phenotype
/
Rh-Hr Blood-Group System
/
Exons
/
Alleles
/
Genotype
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2019
Type:
Article