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Advances in the Diagnosis and Therapy of Double-hit Lymphoma--Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1311-1315, 2019.
Article in Zh | WPRIM | ID: wpr-775723
Responsible library: WPRO
ABSTRACT
Abstract  Double-hit lymphoma (DHL) is a high-grade B-cell lymphoma with MYC and BCL-2/BCL-6 rearrangement, which is a invasive disease with a poor prognosis. FISH is the most important diagnostic method. There is no standard protocol for this disease yet. New therapeutic approaches including targeted therapy,checkpoint inhibitors and chimeric antigen receptor T-cell therapy are changing the paradigm of treatment for DHL. This review summarizes new developments in diagnosis and treatment of double-hit lymphoma.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Immunotherapy, Adoptive / Lymphoma, B-Cell / Proto-Oncogene Proteins c-myc / Proto-Oncogene Proteins c-bcl-2 / Genetic Predisposition to Disease / Proto-Oncogene Proteins c-bcl-6 Type of study: Diagnostic_studies / Guideline Limits: Humans Language: Zh Journal: Journal of Experimental Hematology Year: 2019 Type: Article
Full text: 1 Index: WPRIM Main subject: Immunotherapy, Adoptive / Lymphoma, B-Cell / Proto-Oncogene Proteins c-myc / Proto-Oncogene Proteins c-bcl-2 / Genetic Predisposition to Disease / Proto-Oncogene Proteins c-bcl-6 Type of study: Diagnostic_studies / Guideline Limits: Humans Language: Zh Journal: Journal of Experimental Hematology Year: 2019 Type: Article