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Significance of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Patients with Multiple Myeloma / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1185-1189, 2019.
Article in Chinese | WPRIM | ID: wpr-775744
ABSTRACT
OBJECTIVE@#To investigate the significance of neutrophil/lymphocyte ratio(NLR) and platelet/lymphocyte ratio(PLR) in patients with multiple myeloma (MM).@*METHODS@#Eighty patients with multiple myeloma admitted in our hospital from August 2007 to August 2010 were selected. The clinical data of the patients, including hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), white blood cell(WBC) count, absolute neutrophil count (ANC), platelet count (PC), glomerular filtration rate (GFR), calcium, albumin, β2 microglobulin and so on were collected and analyzed.@*RESULTS@#The optimal threshold of NLR was 2.78 (sensitivity 83.3%, specificity 43.1%). The optimal threshold of PLR was 155.58 (sensitivity 67.7%, specificity 36.9%). All patients were grouped according to NLR and PLR values, patients with high NLR and PLR had lower albumin levels and higher clinical stages. High NLR patients were mainly men, hemoglobin, GFR values, albumin levels were lower, and the white blood cells count and β2 microglobulin level were higher. High PLR patients showed low albumin level and higher clinical stage. Multivariate analysis showed that β2 microglobulin and NLR were prognostic factors in patients with multiple myeloma (P2.78) associates with poor prognosis in patients with MM, and it may be considered as an independent prognostic factor for MM patients.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Blood Platelets / Lymphocytes / Retrospective Studies / Multiple Myeloma / Neutrophils Type of study: Observational study / Prognostic study Limits: Humans / Male Language: Chinese Journal: Journal of Experimental Hematology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Blood Platelets / Lymphocytes / Retrospective Studies / Multiple Myeloma / Neutrophils Type of study: Observational study / Prognostic study Limits: Humans / Male Language: Chinese Journal: Journal of Experimental Hematology Year: 2019 Type: Article