Advances in research on gene and cell therapy for type IV collagen related hereditary kidney diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 179-182, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775783
ABSTRACT
Type IV collagen is a component of the extracellular matrix in the basement membrane. Abnormal secretion or assembly of type IV collagen may lead to kidney lesions resulting in numerous nephropathy symptoms, e.g., Alport syndrome, thin basement membrane nephropathy, and focal segmental glomerulosclerosis. Treatment for type IV collagen-related nephropathy includes drugs, kidney transplantation, gene and cell therapy. However, drugs are not always effective, and kidney transplantation is hindered by the shortage of donors. Moreover, basement membrane nephritis often occurs after kidney transplantation. Therefore, gene and cell therapy probably is the most promising treatment for type IV collagen related nephropathies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Glomerulosclerosis, Focal Segmental
/
Collagen Type IV
/
Cell- and Tissue-Based Therapy
/
Hematuria
/
Nephritis, Hereditary
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS