Serological and molecular genetic analysis of a family with B(A) blood type / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 165-167, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775787
ABSTRACT
OBJECTIVE@#To analyze the blood type of a family with B(A) blood type.@*METHODS@#The serological blood type of the family was determined by routine tube method. Exons 6 and 7 of the ABO gene were amplified by PCR and subjected to Sanger sequencing.@*RESULTS@#Serological testing of the proband and her elder son showed a discrepancy which was initially identified as B(A) subtype. Her husband and second son were identified as blood type O. Sequencing of the proband and her elder son has identified an O allele and a 640A>G mutation compared with the B gene. Her husband and second son possessed the same genotype of O/O.@*CONCLUSION@#The 640A>G mutation of ABO gene probably underlies the B(A) subtype.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
ABO Blood-Group System
/
Exons
/
Alleles
/
Genotype
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2019
Type:
Article
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