Two cases of rare diseases with abnormalities of X chromosome / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 151-153, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775791
ABSTRACT
OBJECTIVE@#To explore the clinical features and genetic diagnosis of two cases with rare diseases and X chromosome abnormalities.@*METHODS@#Multiple ligation-dependent probe amplification (MLPA) and karyotype analysis were carried out on an 8-year-old girl who was diagnosed with Duchenne muscular dystrophy. Karyotype analysis and PCR assay for SRY and AZF genes were carried out for a-2-month-old male infant with short penis.@*RESULTS@#The girl, who featured short stature and cubitus valgus, was diagnosed as Turner syndrome with a karyotype of 46,X,i(Xq). The male infant was detected with a karyotype of 45,X, with presence of SRY gene but absence of AZF gene.@*CONCLUSION@#Both cases may be associated with abnormalities of X chromosome. Genetic testing can facilitate early diagnosis and clinical intervention for such patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Turner Syndrome
/
Muscular Dystrophy, Duchenne
/
Chromosomes, Human, X
/
Rare Diseases
/
Genetics
/
Karyotyping
Type of study:
Screening study
Limits:
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2019
Type:
Article
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