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Two cases of rare diseases with abnormalities of X chromosome / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 151-153, 2019.
Article in Chinese | WPRIM | ID: wpr-775791
ABSTRACT
OBJECTIVE@#To explore the clinical features and genetic diagnosis of two cases with rare diseases and X chromosome abnormalities.@*METHODS@#Multiple ligation-dependent probe amplification (MLPA) and karyotype analysis were carried out on an 8-year-old girl who was diagnosed with Duchenne muscular dystrophy. Karyotype analysis and PCR assay for SRY and AZF genes were carried out for a-2-month-old male infant with short penis.@*RESULTS@#The girl, who featured short stature and cubitus valgus, was diagnosed as Turner syndrome with a karyotype of 46,X,i(Xq). The male infant was detected with a karyotype of 45,X, with presence of SRY gene but absence of AZF gene.@*CONCLUSION@#Both cases may be associated with abnormalities of X chromosome. Genetic testing can facilitate early diagnosis and clinical intervention for such patients.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Turner Syndrome / Muscular Dystrophy, Duchenne / Chromosomes, Human, X / Rare Diseases / Genetics / Karyotyping Type of study: Screening study Limits: Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Turner Syndrome / Muscular Dystrophy, Duchenne / Chromosomes, Human, X / Rare Diseases / Genetics / Karyotyping Type of study: Screening study Limits: Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2019 Type: Article