Role of Tbx20 gene in the development of cardiac valves / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 904-907, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-775807
ABSTRACT
Cardiac valves are highly organized yet delicate structures that ensure unidirectional blood flow through the cardiac chambers and large vessels. Disturbed development of cardiac valves can lead to aberrant heart formation and function which account for approximately one third of congenital heart diseases. The formation of cardiac valves is a dynamic process accomplished by a series of complex events including lineage determination and cell proliferation, differentiation and migration. This paper reviews current knowledge about the role of Tbx20 gene in the development of cardiac valves, which include functional diversities of Tbx20 at various stages of cardiac valve development, its interaction with other signaling pathways, and genetic network involved in endocardial development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Differentiation
/
Embryology
/
Gene Expression Regulation, Developmental
/
T-Box Domain Proteins
/
Cell Proliferation
/
Gene Regulatory Networks
/
Genetics
/
Heart Valves
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2018
Type:
Article
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