Study of genetic polymorphisms of 7 Y chromosome single nucleotide polymorphism loci among Mongolians from Inner Mongolia Region / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 901-903, 2018.
Article
in Zh
| WPRIM
| ID: wpr-775808
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To study the genetic polymorphisms of 7 Y chromosome single nucleotide polymorphisms (Y-SNPs) among unrelated Mongolian males from Inner Mongolia Region.@*METHODS@#Seven Y-SNPs with expected allelic frequencies close to 0.50:0.50 in Mongolian population were selected from databases including HapMap and relevant literature. The Y-SNPs were then analyzed among 95 unrelated male Mongolian DNA samples with ligase detection reaction (LDR) technique. Statistical analysis was carried out with Arlequin 3.5.@*RESULTS@#All of the 7 Y-SNPs had 2 alleles. Seven haplotypes were identified among the 95 samples, with the haplotype diversity (HD) being 0.7990. Except for rs17316007, whose allelic frequencies was 0.832:0.168, each of the remaining Y-SNPs had a allelic frequency close to 0.50:0.50. The gene diversity (GD) for rs17316007 was 0.2825, while those of the remaining Y-SNPs were all greater than 0.4375.@*CONCLUSION@#Except for rs17316007, the other 6 Y-SNPs showed good diversity and genetic polymorphism, and may be used for individual identification and paternity testing for the Inner Mongolia region.
Full text:
1
Index:
WPRIM
Main subject:
Haplotypes
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China
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Polymorphism, Single Nucleotide
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Chromosomes, Human, Y
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Asian People
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Gene Frequency
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Genetics
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Genetics, Population
Limits:
Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2018
Type:
Article