Immunotherapy of Gastrointestinal Stromal Tumors / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 696-701, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-775973
ABSTRACT
Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract and respond poorly to conventional radiochemotherapy.Complete excision is the only possible way to cure GISTs.Although targeted therapy is effective for GISTs,multiple and/or secondary mutations of KIT or PDGFRA gene have lead to increased drug resistance and disease relapse.A variety of tumor infiltrating immune cells and complex immune microenvironments have been found in GISTs.Many immune cells participate in the occurrence and development of GISTs and play key roles in targeted therapy.The feasibility and effectiveness of immunotherapy for GISTs have been well demonstrated in preclinical and clinical studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Proto-Oncogene Proteins c-kit
/
Receptor, Platelet-Derived Growth Factor alpha
/
Gastrointestinal Stromal Tumors
/
Allergy and Immunology
/
Tumor Microenvironment
/
Genetics
/
Immunotherapy
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2019
Type:
Article
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