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Treatment and Prognosis of Adult T Cell Acute Lymphoblastic Leukemia / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 485-491, 2019.
Article in Chinese | WPRIM | ID: wpr-776006
ABSTRACT
To analyze the treatment and prognosis of T cell acute lymphoblastic leukemia(T-ALL)in adults. Method The clinicobiogical and survival data of 68 adult patients with newly diagnosis T-ALL were retrospectively analzyed. Results The median age of these 68 patients was 23 years(14-60 years).T-ALL was more common in men(81%).After the first cycle of treatment,complete remission was achieved in 50 patients(73%).The highest complete remission(CR) rate was in patients with cortex T-ALL(100%),followed by other T-ALL(73%)and early T-cell precursor lymphoblastic leukemia(54%),(=5.712,=0.058).The CR rate for adults aged >35 years was significantly lower than that of patients aged ≤ 35 years(40% 79%,=6.364,=0.012).The overall CR rate after the second treatment course was 93%.For patients treated with chemotherapy,autograft hematopoietic stem cell transplantation(auto-SCT),and allogeneic SCT,the median relapse free survival was 10 months,24 months,and not reached,respectively(=0.002).The 5-year overall survival rate was 25% for all patients;for patients treated with chemotherapy,auto-SCT and allogeneic SCT,the median overall survival was 24 months,34 months,and 30 months,respectively(=0.007),and the 5-year overall survival rate was 9%,33%,and 38%(=0.037).Multivariate analysis showed leukocyte count ≥100×10 /L was a risk factor for decreased relapse free survival(risk ratio 2.540,95%=1.058-6.099,=0.037). Conclusion Adult T-ALL patients have poor prognosis,which may be improved by SCT.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Therapeutics / Remission Induction / Survival Rate / Retrospective Studies / Treatment Outcome / Hematopoietic Stem Cell Transplantation / Disease-Free Survival / Diagnosis / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Therapeutics / Remission Induction / Survival Rate / Retrospective Studies / Treatment Outcome / Hematopoietic Stem Cell Transplantation / Disease-Free Survival / Diagnosis / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2019 Type: Article