Advances in Long Non-coding RNAs on Resistant to EGFR-TKIs
in Non-small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 121-128, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-776368
ABSTRACT
Most non-small cell lung cancer patients with active epidermal growth factor receptor (EGFR) mutation will eventually acquire drug resistant to EGFR tyrosine kinase inhibitors, such as gefitinib, resulting in disease progression, which involves a variety of complex mechanisms. Up to now, the molecular mechanisms of long non-coding RNAs mediated EGFR-TKIs resistance remains poorly understood. This review aims to outline the current state of information on lncRNAs and progress on its role in EGFR-TKIs resistance in non-small cell lung cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Carcinoma, Non-Small-Cell Lung
/
Drug Resistance, Neoplasm
/
Therapeutic Uses
/
Protein Kinase Inhibitors
/
Drug Therapy
/
RNA, Long Noncoding
/
ErbB Receptors
/
Genetics
/
Lung Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Type:
Article
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