Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy--
AKT/m-TOR Pathway and Resistance to Cancer Therapy / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 63-66, 2018.
Article
in English
| WPRIM
| ID: wpr-776376
ABSTRACT
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Signal Transduction
/
Biomarkers, Tumor
/
Drug Resistance, Neoplasm
/
Drug Therapy
/
Proto-Oncogene Proteins c-akt
/
TOR Serine-Threonine Kinases
/
Molecular Targeted Therapy
/
Metabolism
/
Methods
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Type:
Article
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