Research Progress in the Therapeutic Strategy Based on Targeting at
Lung Cancer Stem Cell / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 57-62, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-776377
ABSTRACT
With high morbidity and mortality, lung cancer is a major threat to human health and one of the focuses of tumor researches. Lung cancer stem cells (LCSCs) are regarded as a subpopulation of cells within lung cancer tissues with the capacity of self-renewal and differentiation, and might be related to tumorigenesis and heterogeneity of lung cancer. Tumor recurrence, metastasis and drug resistance of lung cancers could be clarified by LCSC hypothesis. Thus it's therapeutically prospective to target at these cells. This review summarizes the biomarkers of LCSCs and their aberrant signal pathways, as well as the therapeutic strategies targeting at LCSCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Neoplastic Stem Cells
/
Signal Transduction
/
Drug Therapy
/
Molecular Targeted Therapy
/
Lung Neoplasms
/
Methods
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Type:
Article
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