Prognosis-related miRNA bioinformatics screening of lung adenocarcinoma and its clinical significance / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 530-535, 2018.
Article
in Zh
| WPRIM
| ID: wpr-776578
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the prognosis-related miRNA histological features and clinical significance of lung adenocarcinoma.@*METHODS@#Using The Cancer Genome Atlas (TCGA) data, the miRNA expression profile data of human lung adenocarcinoma were searched for differential analysis, and the prognosis-related miRNAs were screened by Cox risk regression model. The targeted miRNAs were predicted by mirwalk analysis platform, KEGG functional enrichment analysis, and finally, predict the function of prognosis-related miRNAs.@*RESULTS@#A total of 46 differential miRNAs in lung adenocarcinoma were screened, including 19 up-regulated and 27 down-regulated. Six prognostic-related miRNAs were screened by Cox survival analysis, namely hsa-mir-21, hsa-mir-142, hsa-mir-200a high expression, hsa-mir-101, hsa-let-7c, hsa-mir-378e low expression, hsa-mir-21 and hsa-mir-378e were associated with poor prognosis in patients with lung adenocarcinoma, and the survival time was shortened significantly (<0.05, AUC=0.618). KEGG analysis showed that the above prognosis-related miRNA targeting regulatory genes were related with immune response pathways, miRNA and cancer pathways, metabolic pathways and so on.@*CONCLUSIONS@#Hsa-mir-21 and hsa-mir-378e are associated with poor prognosis of lung adenocarcinoma, and may be used as a molecular marker for prognosis of lung adenocarcinoma after further clinical verification.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
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Biomarkers, Tumor
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Gene Expression Regulation, Neoplastic
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Computational Biology
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MicroRNAs
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Adenocarcinoma of Lung
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Lung Neoplasms
Type of study:
Diagnostic_studies
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Prognostic_studies
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Screening_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2018
Type:
Article