Clinical features and risk factors of pertussis in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1034-1039, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-776671
ABSTRACT
OBJECTIVE@#To study the clinical features and risk factors of pertussis in children.@*METHODS@#A retrospective analysis was performed for the clinical data and laboratory markers for immune function of 253 hospitalized children with pertussis. A total of 314 hospitalized children with cough were used as the control group. Quantitative real-time PCR was used to detect Bordetella pertussis DNA. The clinical data of both groups were collected to analyze the risk factors for pertussis.@*RESULTS@#A total of 23 typical clinical parameters were compared between the pertussis and control groups, and there were significant differences in only 10 clinical parameters between the two groups (P<0.01). As for the complications observed in the two groups, the pertussis group had a significantly lower incidence rate of myocarditis than the control group (P<0.05). The pertussis group had significantly lower levels of serum globulin and IgM than the control group (P<0.05). Compared with the control group, the pertussis group had a significantly higher proportion of children with a lack of diphtheria-pertussis-tetanus immunization or timely immunization and a contact history of suspected pertussis patients (P<0.05). A lack of vaccine immunization or timely immunization and a contact history of suspected pertussis patients were risk factors for pertussis (P<0.05).@*CONCLUSIONS@#The clinical features are not typical in children with pertussis. Quantitative real-time PCR for detecting Bordetella pertussis DNA helps with the early diagnosis of atypical pertussis. Infants/toddlers should be immunized in time and be isolated from suspected pertussis patients to reduce the incidence of pertussis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bordetella pertussis
/
Diphtheria-Tetanus-Pertussis Vaccine
/
Whooping Cough
/
Retrospective Studies
/
Risk Factors
Type of study:
Etiology study
/
Observational study
/
Risk factors
/
Screening study
Limits:
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Type:
Article
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