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Protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1020-1023, 2018.
Article in Chinese | WPRIM | ID: wpr-776674
ABSTRACT
OBJECTIVE@#To study the protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus (T1DM) and its mechanism.@*METHODS@#A total of 46 children with T1DM (with a course of disease of 0.5-1 year) were randomly divided into an intervention group and a non-intervention group (n=23 each). The children in both groups were given insulin treatment, and those in the intervention group were also given vitamin A at a daily dose of 1 500-2 000 IU. A total of 25 healthy children were enrolled as the control group. The daily dose of insulin was calculated for the children with T1DM, and the serum levels of glycosylated hemoglobin (HbA1C), stimulated C-peptide, vitamin A, and interleukin-17 (IL-17) were measured before intervention and 3 months after intervention.@*RESULTS@#Before vitamin A intervention, the intervention group and the non-intervention group had a significantly lower serum level of vitamin A and a significantly higher level of IL-17 than the control group (P<0.01). After 3 months of intervention, the intervention group had significantly lower serum IL-17 level and insulin dose and a significantly higher level of stimulated C-peptide than the non-intervention group (P<0.05).@*CONCLUSIONS@#Vitamin A may protect residual pancreatic β cell function, possibly by improving the abnormal secretion of IL-17 in children with T1DM.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitamin A / Blood Glucose / C-Peptide / Glycated Hemoglobin / Diabetes Mellitus, Type 1 / Insulin-Secreting Cells / Insulin Limits: Humans / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitamin A / Blood Glucose / C-Peptide / Glycated Hemoglobin / Diabetes Mellitus, Type 1 / Insulin-Secreting Cells / Insulin Limits: Humans / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2018 Type: Article