Advances in the treatment of juvenile myelomonocytic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 958-963, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-776685
ABSTRACT
Juvenile myelomonocytic leukemia (JMML) is a rare chronic myeloid leukemia in children and has the features of both myelodysplastic syndrome and myeloproliferative neoplasm. It is highly malignant and has a poor treatment outcome. Children with JMML have a poor response to conventional chemotherapy. At present, hematopoietic stem cell transplantation is the only possible cure for this disease. In recent years, significant progress has been made in targeted therapy for mutant genes in the Ras signaling pathway and demethylation treatment of aberrant methylation of polygenic CpG islands. This article reviews the treatment and efficacy evaluation of JMML.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Myelodysplastic Syndromes
/
Signal Transduction
/
Hematopoietic Stem Cell Transplantation
/
Leukemia, Myelomonocytic, Juvenile
/
Methylation
Limits:
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Type:
Article
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