Cell models and drug discovery for mitochondrial diseases / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
J. Zhejiang Univ., Sci. B (Internet)
; (12): 449-456, 2019.
Article
in En
| WPRIM
| ID: wpr-776718
Responsible library:
WPRO
ABSTRACT
Mitochondrion is a semi-autonomous organelle, important for cell energy metabolism, apoptosis, the production of reactive oxygen species (ROS), and Ca homeostasis. Mitochondrial DNA (mtDNA) mutation is one of the primary factors in mitochondrial disorders. Though much progress has been made, there remain many difficulties in constructing cell models for mitochondrial diseases. This seriously restricts studies related to targeted drug discovery and the mechanism and therapy for such diseases. Here we summarize the characteristics of patient-specific immortalized lymphoblastoid cells, fibroblastoid cells, cytoplasmic hybrid (cybrid) cell lines, and induced pluripotent stem cells (iPSCs)-derived differentiation cells in the study of mitochondrial disorders, as well as offering discussion of roles and advances of these cell models, particularly in the screening of drugs.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
En
Journal:
J. Zhejiang Univ., Sci. B (Internet)
Year:
2019
Type:
Article