A case with a novel weak D type / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 731-733, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-776818
ABSTRACT
OBJECTIVE@#To report on a novel weak D type identified in a Chinese individual.@*METHODS@#Peripheral blood sample was collected for a voluntary blood donor with weakened expression of D antigen. Routine serological testing was carried out to determine the D, C, c, E and e antigens of the Rh blood group. A D-screening kit was used to analyze the RhD epitopes. The 10 exons and flanking intronic regions of the RHD gene were sequenced. The zygosity of RHD was determined with a sequence-specific primer PCR method.@*RESULTS@#A novel RHD allele, RHD (1022T>A), was found in the subject with a weak D phenotype. Serological testing of the RhD epitopes has coined with the weak D phenotype.@*CONCLUSION@#A novel weak D allele has been identified in Chinese population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rh-Hr Blood-Group System
/
Introns
/
China
/
Exons
/
Asian People
/
Alleles
/
Genetics
/
Genotype
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2019
Type:
Article
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