Bioactive phenazines from an earwig-associated Streptomyces sp / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 475-480, 2019.
Article
in English
| WPRIM
| ID: wpr-776863
ABSTRACT
Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a biosynthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenazines
/
Streptomyces
/
Bacterial Proteins
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Microbial Sensitivity Tests
/
Chemistry
/
Multigene Family
/
Micrococcus luteus
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article
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