Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 298-302, 2019.
Article
in English
| WPRIM
| ID: wpr-776883
ABSTRACT
Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC of 13.44 ± 0.28 μmol·L, being comparable to the positive control, quercetin (IC 17.00 ± 2.10 μmol·L).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Carbon
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Lipopolysaccharides
/
Plant Stems
/
Inhibitory Concentration 50
/
Jatropha
/
Diterpenes
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article
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