Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 291-297, 2019.
Article
in English
| WPRIM
| ID: wpr-776884
ABSTRACT
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Seeds
/
Drug Screening Assays, Antitumor
/
Plant Extracts
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
Drug Resistance, Neoplasm
/
Annona
/
Cell Line, Tumor
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS