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Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 291-297, 2019.
Article in English | WPRIM | ID: wpr-776884
ABSTRACT
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Seeds / Drug Screening Assays, Antitumor / Plant Extracts / Molecular Structure / Cell Survival / Chemistry / Drug Resistance, Neoplasm / Annona / Cell Line, Tumor Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Seeds / Drug Screening Assays, Antitumor / Plant Extracts / Molecular Structure / Cell Survival / Chemistry / Drug Resistance, Neoplasm / Annona / Cell Line, Tumor Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article