Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 227-230, 2019.
Article
in English
| WPRIM
| ID: wpr-776890
ABSTRACT
Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC being 37.41 μmol·L.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Melia azedarach
/
Limonins
/
Fruit
/
Macrophages
/
Metabolism
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article
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