Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 155-160, 2019.
Article
in English
| WPRIM
| ID: wpr-776897
ABSTRACT
Romipeptides A and B (1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A (3), romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis. Compounds 1-5 were evaluated for their anti-proliferative activities against three human cancer cell lines, SW620, HL60, and A549. The results showed most of these compounds exhibited antitumor activities in vitro, in which compound 2 displayed potent cytotoxicity to SW620, HL60 and A549 cell lines, with IC of 12.5, 6.7 and 5.7 nmol·L, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides, Cyclic
/
Pharmacology
/
Drug Screening Assays, Antitumor
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
Chemistry Techniques, Analytical
/
Chromobacterium
/
Cell Line, Tumor
/
Depsipeptides
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2019
Type:
Article
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