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Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 149-154, 2019.
Article in English | WPRIM | ID: wpr-776898
ABSTRACT
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC being 5.11 ± 0.53 μmol·L, and acted as a noncompetitive inhibitor based on kinetic analysis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Pharmacology / Porifera / Aspergillus / 4-Butyrolactone / Molecular Structure / Chemistry / Chemistry Techniques, Analytical / Protein Tyrosine Phosphatases / Dipeptides Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Pharmacology / Porifera / Aspergillus / 4-Butyrolactone / Molecular Structure / Chemistry / Chemistry Techniques, Analytical / Protein Tyrosine Phosphatases / Dipeptides Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2019 Type: Article