AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 527-533, 2018.
Article
in English
| WPRIM
| ID: wpr-777035
ABSTRACT
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Protein-Tyrosine Kinases
/
Cell Differentiation
/
Cells, Cultured
/
Oligodendroglia
/
Demyelinating Diseases
/
Rats, Sprague-Dawley
/
Gene Expression Regulation, Developmental
/
Myelin Proteolipid Protein
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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