Membrane Aging as the Real Culprit of Alzheimer's Disease: Modification of a Hypothesis / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 369-381, 2018.
Article
in English
| WPRIM
| ID: wpr-777056
ABSTRACT
Our previous studies proposed that Alzheimer's disease (AD) is a metabolic disorder and hypothesized that abnormal brain glucose metabolism inducing multiple pathophysiological cascades contributes to AD pathogenesis. Aging is one of the great significant risk factors for AD. Membrane aging is first prone to affect the function and structure of the brain by impairing glucose metabolism. We presume that risk factors of AD, including genetic factors (e.g., the apolipoprotein E ε4 allele and genetic mutations) and non-genetic factors (such as fat, diabetes, and cardiac failure) accelerate biomembrane aging and lead to the onset and development of the disease. In this review, we further modify our previous hypothesis to demonstrate "membrane aging" as an initial pathogenic factor that results in functional and structural alterations of membranes and, consequently, glucose hypometabolism and multiple pathophysiological cascades.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Brain
/
Aging
/
Cell Membrane
/
Alzheimer Disease
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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