Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 549-565, 2018.
Article
in English
| WPRIM
| ID: wpr-777058
ABSTRACT
Epilepsy is one of the most common neurological diseases. Of all cases, 70%-80% are considered to be due to genetic factors. In recent years, a large number of genes have been identified as being involved in epilepsy. Among them, N-methyl-D-aspartate receptor (NMDAR) subunit-encoding genes represent a large proportion, suggesting an important role for NMDARs in epilepsy. In this review, we summarize and analyze the genotypes, functional alterations, and clinical aspects of NMDAR subunit mutations/variants identified from patients with epilepsy. These data will help to throw light upon the pathogenicity of these NMDAR mutations and advance our understanding of the subtle and complicated role of NMDARs in epilepsy. It will also offer new insights into precision therapy for this disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, N-Methyl-D-Aspartate
/
Genetic Predisposition to Disease
/
Epilepsy
/
Genetics
/
Mutation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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