Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 200-207, 2018.
Article
in English
| WPRIM
| ID: wpr-777071
ABSTRACT
Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single-cell transcriptomes, cell types, and functional annotations of somatosensory neurons have been studied. In this review, we introduce our classification of DRG neurons based on single-cell RNA-sequencing and functional analyses, and discuss the technical approaches. Moreover, studies on the molecular and cellular mechanisms underlying somatic sensations are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Pathology
/
Sensory Receptor Cells
/
Sequence Analysis, RNA
/
Cell Biology
/
Gene Regulatory Networks
/
Transcriptome
/
Ganglia, Spinal
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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