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Spinal Circuits Transmitting Mechanical Pain and Itch / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 186-193, 2018.
Article in English | WPRIM | ID: wpr-777076
ABSTRACT
In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch. We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli, a hallmark symptom for many chronic pain or itch patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain / Pathology / Physiology / Pruritus / Spinal Cord / Synaptic Transmission / Nerve Net Limits: Animals / Humans Language: English Journal: Neuroscience Bulletin Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain / Pathology / Physiology / Pruritus / Spinal Cord / Synaptic Transmission / Nerve Net Limits: Animals / Humans Language: English Journal: Neuroscience Bulletin Year: 2018 Type: Article