Spinal Mechanisms of Itch Transmission / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 156-164, 2018.
Article
in English
| WPRIM
| ID: wpr-777082
ABSTRACT
Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide (GRP)-GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Physiology
/
Pruritus
/
Sensory Receptor Cells
/
Spinal Cord
/
Action Potentials
/
Synaptic Transmission
/
Analgesics, Opioid
/
Metabolism
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2018
Type:
Article
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