Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance / 生理学报
Acta Physiologica Sinica
;
(6): 741-748, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-777136
ABSTRACT
Rodent MrgC receptor (Mas-related G-protein-coupled receptor subtype C) shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1 (hMrgX1). Therefore, researchers generally explore the role of hMrgX1 by studying the function of MrgC receptor. Murine MrgC receptor is uniquely expressed in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia (TG), which is closely related to the transmission process of pain. This review summarizes the analgesic effects of intrathecal activation of MrgC receptors in pathological pain and morphine tolerance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain
/
Peptide Fragments
/
Pharmacology
/
Physiology
/
Trigeminal Ganglion
/
Rats, Sprague-Dawley
/
Receptors, G-Protein-Coupled
/
Drug Tolerance
/
Ganglia, Spinal
/
Morphine
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2019
Type:
Article
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