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Research progress on neural mechanism of peripheral inflammation in Parkinson's disease / 生理学报
Acta Physiologica Sinica ; (6): 732-740, 2019.
Article in Chinese | WPRIM | ID: wpr-777137
ABSTRACT
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found that microglial cell activation and increased levels of pro-inflammatory factors were common features of PD brain tissue. At the same time, the invasion and accumulation of peripheric immune cells were detected in the brain of PD patients. In this paper, peripheral inflammation across the blood-brain barrier (BBB), the misfolded α-synuclein (α-syn)-induced microglial cell activation and intracerebral inflammation in PD are summarized, providing potential therapeutic measures for delaying the onset of PD.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Pathology / Substantia Nigra / Blood-Brain Barrier / Microglia / Alpha-Synuclein / Dopaminergic Neurons / Inflammation Limits: Animals / Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Pathology / Substantia Nigra / Blood-Brain Barrier / Microglia / Alpha-Synuclein / Dopaminergic Neurons / Inflammation Limits: Animals / Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2019 Type: Article