Research update of Klotho in kidney injury and repair / 生理学报
Acta Physiologica Sinica
;
(6): 639-643, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-777220
ABSTRACT
Klotho is highly expressed in the kidney, while soluble Klotho is detectable in the blood, urine, and cerebrospinal fluid, and has multiple hormone-like functions. The role of Klotho in kidney injury has attracted more and more attentions from researchers. Emerging evidence revealed that the transient deficiency of Klotho is an early event of acute kidney injury (AKI), whereas, in chronic kidney disease, this deficiency is sustained not only in the kidney, but also in other organ systems. Therefore, Klotho could be a potential biomarker for early diagnosis of AKI, as well as for its progression to chronic kidney disease. Moreover, Klotho might have therapeutic value to renal injury. Nevertheless, there are only few studies on the involvement of Klotho in post AKI repair. This review focused on the role of Klotho in not only kidney injury, but also its repair, in particular the relationship between Klotho and cell fate (autophagy/apoptosis/necrosis), repair/regeneration, Wnt/β-catenin and erythropoietin receptor, one of the Klotho effectors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Biomarkers
/
Signal Transduction
/
Disease Progression
/
Acute Kidney Injury
/
Glucuronidase
/
Kidney
/
Metabolism
Type of study:
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2018
Type:
Article
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