New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension / 生理学报
Acta Physiologica Sinica
;
(6): 581-590, 2018.
Article
in English
| WPRIM
| ID: wpr-777227
ABSTRACT
Fructose intake has increased dramatically over the past century and the upward trend has continued until recently. Increasing evidence suggests that the excessive intake of fructose induces salt-sensitive hypertension. While the underlying mechanism is complex, the kidney likely plays a major role. This review will highlight recent advances in the renal mechanisms of fructose-induced salt-sensitive hypertension, including (pro)renin receptor-dependent activation of intrarenal renin-angiotensin system, increased nephron Na transport activity via sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter, increased renal uric acid production, decreased renal nitric oxide production, and increased renal reactive oxygen species production, and suggest actions based on these mechanisms that have therapeutic implications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Renin-Angiotensin System
/
Uric Acid
/
Blood Pressure
/
Reactive Oxygen Species
/
Sodium Chloride, Dietary
/
Sodium-Hydrogen Exchanger 3
/
Fructose
/
Hypertension
/
Kidney
/
Metabolism
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2018
Type:
Article
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